The author of 《Discovery, synthesis, biological evaluation and molecular docking study of (R)-5-methylmellein and its analogs as selective monoamine oxidase A inhibitors》 were Huang, Chao; Xiong, Juan; Guan, Hui-Da; Wang, Chang-Hong; Lei, Xinsheng; Hu, Jin-Feng. And the article was published in Bioorganic & Medicinal Chemistry in 2019. Quality Control of 2-Pyridinylboronic acid The author mentioned the following in the article:
Nonracemic hydroxydihydroisobenzopyranones such as I, analogs of (R)-5-methylmellein, were prepared and tested as inhibitors of monoamine oxidase A (MAO-A). Most of the hydroxydihydrobenzopyranones selectively inhibited MAO-A with IC50 values of 60 nM to 29 μM; I was the most potent and selective analog prepared, with IC50 values of 60 nM for MAO-A and >50 μM for MAO-B. Mol. docking calculations of I in the active sites of MAO-A and MAO-B were performed; the kinetics of inhibition of MAO-A by I were determined In the experimental materials used by the author, we found 2-Pyridinylboronic acid(cas: 197958-29-5Quality Control of 2-Pyridinylboronic acid)
2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Quality Control of 2-Pyridinylboronic acid