In 2019,Chemistry – A European Journal included an article by Sinha, Narayan; Champagne, Pier Alexandre; Rodriguez, Michael J.; Lu, Yu; Kopach, Michael E.; Mitchell, David; Organ, Michael G.. Quality Control of 5-Bromo-2-chloropyridine. The article was titled 《One-Pot Sequential Kumada-Tamao-Corriu Couplings of (Hetero)Aryl Polyhalides in the Presence of Grignard-Sensitive Functional Groups Using Pd-PEPPSI-IPentCl》. The information in the text is summarized as follows:
We report a general and rapid chemoselective Kumada-Tamao-Corriu (KTC) cross-coupling of aryl bromides in the presence of chlorides or triflates with functionalized Grignard reagents at 0 °C in 15 min by using Pd-PEPPSI-IPentCl (C4) [e.g., 1-bromo-4-chlorobenzene + (4-cyanophenyl)magnesium bromide → 4′-chlorobiphenyl-4-carbonitrile (91% isolated) in presence of C4 (I)].. Nucleophiles and electrophiles (or both) can contain Grignard-sensitive functional groups (-CN, -COOR, etc.). Control experiments together with DFT calculations suggest that transmetallation is rate limiting for the selective cross-coupling of Br in the presence of Cl/OTf with functionalized Grignard reagents. One-pot sequential KTC/KTC cross-couplings with bromo-chloro arenes have been demonstrated for the first time. We also report the one-pot sequential KTC/Negishi cross-couplings using C4 showcasing the versatility of this methodol.5-Bromo-2-chloropyridine(cas: 53939-30-3Quality Control of 5-Bromo-2-chloropyridine) was used in this study.
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Quality Control of 5-Bromo-2-chloropyridine