The author of 《Chiral Calcium Iodide for Asymmetric Mannich-type Reactions of Malonates with Imines Providing β-Aminocarbonyl Compounds》 were Tsubogo, Tetsu; Shimizu, Shota; Kobayashi, Shu. And the article was published in Chemistry – An Asian Journal in 2013. Synthetic Route of C35H27N3O2 The author mentioned the following in the article:
We have developed a novel chiral calcium iodide catalyst prepared from CaI2 and pybox [2,6-bis(2-oxazolinyl)pyridine] that is stable under moisture and oxygen. This catalyst was applied to catalytic asym. Mannich-type reactions of malonates with both N-Boc-protected aromatic and aliphatic imines, and gave moderate to high yields of β-aminocarbonyl compounds with high enantioselectivities. The Mannich adduct was also successfully converted into an α-hydroxy β-amino acid derivative In the experiment, the researchers used 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7Synthetic Route of C35H27N3O2)
2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Synthetic Route of C35H27N3O2 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.