Wang, Yuanjiang; Lv, Zhaodan; Chen, Feihong; Wang, Xing; Gou, Shaohua published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《Discovery of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine Derivatives as Highly Selective CK2 Inhibitors with Potent Cancer Cell Stemness Inhibition》.HPLC of Formula: 103-74-2 The article contains the following contents:
Multifunctional entities have recently been attractive for the development of anticancer chemotherapeutic drugs. However, such entities with concurrent CK2 along with cancer stem cell (CSC) inhibitory activities are rare in a single small mol. Herein, a series of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine derivatives were synthesized using a known CK2 inhibitor, silmitasertib (CX-4945), as the lead compound Among the resulting compounds, 5-((3-chlorophenyl)amino)-N-(2-hydroxyethyl)benzo[c][2,6]naphthyridine-8-carboxamide exhibited stronger CK2 inhibitory activity with higher Clk2/CK2 selectivity than CX-4945. Significantly, 5-((3-chlorophenyl)amino)-N-(2-hydroxyethyl)benzo[c][2,6]naphthyridine-8-carboxamide could modulate the Akt1(ser129)-GSK-3β(ser9)-Wnt/β-catenin signaling pathway and inhibit the expression of the stemness marker ALDH1A1, CSC surface antigens, and stem genes, showing potent CSC inhibitory activity. Moreover, 5-((3-chlorophenyl)amino)-N-(2-hydroxyethyl)benzo[c][2,6]naphthyridine-8-carboxamide also displayed superior pharmacokinetics and antitumor activity compared with CX-4945 sodium salt, without obvious toxicity. The favorable antiproliferative and antitumor activity of 5-((3-chlorophenyl)amino)-N-(2-hydroxyethyl)benzo[c][2,6]naphthyridine-8-carboxamide, its high inhibitory selectivity for CK2, and its potent inhibition of cancer cell stemness make this mol. a candidate for the treatment of cancer. After reading the article, we found that the author used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2HPLC of Formula: 103-74-2)
2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. HPLC of Formula: 103-74-2