Zhang, Yongsheng; Wang, Jincheng; Yang, Zhenjiao; Zhang, Zeng; He, Xiaoyan; Chen, Guoliang; Huang, Gang; Lu, Xiuhong published their research in Journal of Organic Chemistry in 2021. The article was titled 《Hydrazine Hydrate Accelerates Neocuproine-Copper Complex Generation and Utilization in Alkyne Reduction, a Significant Supplement Method for Catalytic Hydrogenation》.Computed Properties of C7H5N The article contains the following contents:
An in situ neocuproine-copper complex formation method was reported. The redox potential of this complex enable it can serve as an ideal redox catalyst in the synthesis of diimine by oxidation of hydrazine hydrate and this technique was successfully applied in the reduction of alkynes. This reduction method displayed a broad functional group tolerance and substrate adaptability as well as the advantages of safety and high efficiency. Especially, nitro, benzyl, boc and sulfur containing alkynes can be reduced to the corresponding alkanes directly, which provides a useful complementary method to traditional catalytic hydrogenation. Besides, this method was applied in the preparation of the Alzheimer’s disease drug CT-1812 and studied the mechanism.4-Ethynylpyridine(cas: 2510-22-7Computed Properties of C7H5N) was used in this study.
4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Computed Properties of C7H5N