Formula: C33H24IrN3In 2019 ,《Merging Visible-Light Photoredox and Organoamine Catalysis for the C-3 Difluoroalkylation of Quinoxalin-2(1H)-Ones》 appeared in Asian Journal of Organic Chemistry. The author of the article were Jin, Can; Zhuang, Xiaohui; Sun, Bin; Li, Deyu; Zhu, Rui. The article conveys some information:
A mild and efficient protocol for visible-light and organoamine cocatalyzed difluoroalkylation of quinoxalin-2(1H)-ones with functionalized difluoromethyl bromides was developed. The transformation was carried out at room temperature and gave a variety of C-3 difluoroalkylated quinoxaline-2(1H)-ones in moderate to excellent yields. Moreover, mechanistic studies revealed that this transformation proceeded through a radical-type debrominative coupling process with only need of catalytic amount of diisopropylethylamine (DIPEA). This strategy featured wide functional group tolerance, excellent regioselectivity, mild conditions and operational simplicity. In the experiment, the researchers used fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Formula: C33H24IrN3)
fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Formula: C33H24IrN3