Reference of 4-CyanopyridineIn 2022 ,《Electrochemical Ammonium Cation-Assisted Hydropyridylation of Ketone-Activated Alkenes: Experimental and Computational Mechanistic Studies》 appeared in Advanced Synthesis & Catalysis. The author of the article were Yang, Jianjing; Ma, Jing; Yan, Kelu; Tian, Laijin; Li, Bingwen; Wen, Jiangwei. The article conveys some information:
This work described an electrochem. ammonium cation enabled hydropyridylation of ketone-activated alkenes under metal- and exogenous reductant free conditions giving access to β-pyridyl ketones, through dual proton-coupled electron transfer and radical cross-coupling. It featured a broad substrate scope and allows a gram-scale synthesis. Ammonium chloride played various roles in this transformation such as the hydrogen donor, the protonation reagent and electrolyte. In particular, various experiments and d. functional theory (DFT) calculation results showed the mechanism of dual proton-coupled electron transfer followed by radical cross-coupling was the preferred pathway.4-Cyanopyridine(cas: 100-48-1Reference of 4-Cyanopyridine) was used in this study.
4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Reference of 4-Cyanopyridine