Quality Control of 2-Bromo-5-methylpyridineIn 2020 ,《Synthesis of Decahydrocyclobuta[cd]indene Skeletons: Rhodium(III)-Catalyzed Hydroarylation and Relay Thiophene-Promoted Intramolecular [2+2] Cycloaddition》 appeared in Advanced Synthesis & Catalysis. The author of the article were Gao, Dingding; Wang, Feng; Liu, Xing-Yu; Feng, Kai-Rui; Zhao, Jia-Ying; Wang, Yu-Hui; Yang, Xiao-Di; Tian, Ping; Lin, Guo-Qiang. The article conveys some information:
The preparation of decahydrocyclobuta[cd]indene skeleton was accomplished through rhodium(III)-catalyzed hydroarylation and relay thiophene-promoted intramol. [2+2] cycloaddition This tandem reaction exhibited broad substrate scope (24 examples) and good functional group compatibility. Control experiments revealed the important role of sulfur (S) heteroatom, thus a tentative mechanism with thiophene-promoted double Michael additions was proposed to explain this formal [2+2] cycloaddition Moreover, the resulting polycyclic products displayed potent anti-cancer activities against breast cancer cell lines MDA-MB-468. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Quality Control of 2-Bromo-5-methylpyridine)
2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Quality Control of 2-Bromo-5-methylpyridine