Related Products of 98-98-6In 2019 ,《Half-sandwich iridium(III) complexes with α-picolinic acid frameworks and antitumor applications》 appeared in Journal of Inorganic Biochemistry. The author of the article were Hao, Hailong; Liu, Xicheng; Ge, Xingxing; Zhao, Yao; Tian, Xue; Ren, Ting; Wang, Yan; Zhao, Chengfeng; Liu, Zhe. The article conveys some information:
Eight half-sandwich iridiumIII (IrIII) complexes of the general formula [(η5-Cpxbiph)Ir(ON̂)Cl] (Cpxbiph is tetramethyl(biphenyl)cyclopentadienyl, and the ON̂ is α-picolinic acid chelating ligand and its derivatives) were synthesized and characterized. Compared with cis-platin widely used in clinic, target IrIII complexes showed at most five times more potent antitumor activity against A549 cells by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. IrIII complexes could be transported by serum albumin, bind with DNA, catalyze the oxidation of nicotinamide-adenine dinucleotid (NADH) and induce the production of reactive oxygen species, which confirmed the antitumor mechanism of oxidation IrIII complexes could enter A549 cells followed by an energy-dependent cellular uptake mechanism, meanwhile, target the mitochondria and lysosomes with the Pearson’s colocalization coefficient of 0.33 and 0.74, resp., lead to the lysosomal destruction and the change of mitochondrial membrane potential (ΔΨm), and eventually induce apoptosis. In addition to this study using Picolinic acid, there are many other studies that have used Picolinic acid(cas: 98-98-6Related Products of 98-98-6) was used in this study.
Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Related Products of 98-98-6