Ouchi, Hitoshi; Asahina, Aya; Asakawa, Tomohiro; Inai, Makoto; Hamashima, Yoshitaka; Kan, Toshiyuki published the artcile< Practical Total Syntheses of Acromelic Acids A and B>, Computed Properties of 777931-67-6, the main research area is acromelic acid A B total synthesis; asym conjugate addition intramol reductive amination epimerization.
Practical total syntheses of acromelic acids A (I) and B (II), which have potent neuro-excitatory activity, were accomplished in 13 (36% total yield) and 17 steps (6.9% total yield), resp., from 2,6-dichloropyridine. Regioselective transformation of sym. 2,6-dichloropyridine provided nitroalkenes III and IV. The pyrrolidine ring was efficiently constructed by Ni-catalyzed asym. conjugate addition followed by intramol. reductive amination.
Organic Letters published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 777931-67-6 belongs to class pyridine-derivatives, and the molecular formula is C6H5BrClNO, Computed Properties of 777931-67-6.