Li, Guo-Xing; Hu, Xiafei; He, Gang; Chen, Gong published the artcile< Photoredox-mediated remote C(sp3)-H heteroarylation of free alcohols>, Application of C7H7NO2, the main research area is alc heteroaryl preparation regioselective chemoselective; heteroarene aliphatic alc heteroarylation.
An efficient and economical method for remote δ C(sp3)-H heteroarylation of free aliphatic alcs., e.g., cyclobutaneethanol using a hypervalent iodine PFBI-OH oxidant under photoredox catalysis has been reported. The reaction sequence involves in situ alcoholysis of PFBI-OH with alc., generation of an alkoxy radical intermediate by SET reduction, 1,5-HAT, and Minisci-type C-C bond formation. This method uses a slight excess of alcs., can facilitate reaction at δ Me and methylene positions, and has been successfully applied to modification of complex drug mols.
Chemical Science published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application of C7H7NO2.