Zhang, Rui-Qian; Liu, Zhan-Qing; Luo, Yan-Ling; Xu, Feng; Chen, Ya-Shao published the artcile< Tri-stimuli responsive carbon nanotubes covered by mesoporous silica graft copolymer multifunctional materials for intracellular drug delivery>, Application In Synthesis of 2127-03-9, the main research area is carbon silica graft copolymer multifunctional material intracellular drug delivery.
To overcome premature drug leakage and instability in drug delivery systems, we designed tri-stimuli responsive multiwalled carbon nanotubes covered by mesoporous silica graft poly(N-isopropylacrylamide-block-poly(2-(4-formylbenzoyloxy)) Et methacrylate) multifunctional materials via disulfide linkages (MWCNTs@MSN-s-s-g-PNIPAM-b-PFBEMA). The multifunctional materials could covalently bind and phys. load anticancer drug doxorubicin (DOX), and exhibited pH-, temperature- and reductant-induced multi-stimuli responsiveness, significantly enhancing drug loading capacity and improving the release dynamics of drug. The DOX-loaded multifunctional materials exhibited the optimal release behavior in cancer environments compared with in normal cells upon simultaneously triggered by these stimuli. It meant that the MWCNTs@MSN-s-s-g-PNIPAM-b-PFBEMA could serve as efficient gatekeepers to control the mesopore on-off and thus to modulate drug release. The multifunctional materials were proved to be low toxic, whereas the DOX-loaded counterparts had almost the same toxicity as free DOX to cancer cells. Therefore, the developed multifunctional materials can be used as promising drug controlled delivery platforms for cancer therapy.
Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about Binding energy. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Application In Synthesis of 2127-03-9.