Zhang, Keping; Ding, Chengqiang; Liu, Xiaolin; Gao, Jun; Wu, Datong; Qin, Yong; Kong, Yong published the artcile< A redox and pH dual-triggered drug delivery platform based on chitosan grafted tubular mesoporous silica>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is chitosan tubular mesoporous silica hydrogen ion concentration drug delivery.
Tubular mesoporous silica (T-mSiO2) was facilely synthesized through a co-template method by using cetyltrimethylammonium bromide and α-Fe2O3 as the dual templates, and then disulfide (-SS-) bonds and carboxyl groups (-COOH) were introduced to the resultant T-mSiO2 via the reaction with 2-carboxyethyl 2-pyridyl disulfide. The obtained -SS- grafted T-mSiO2 (SS-T-mSiO2) was then grafted with chitosan (CS) via the amidation reaction between the -COOH groups on SS-T-mSiO2 and the -NH2 groups on CS. The CS grafted SS-T-mSiO2 (CS-SS-T-mSiO2) was fully characterized by various technologies such as transmission electron microscopy, energy dispersive X-ray spectroscopy and Fourier transform IR spectroscopy. Finally, the as-synthesized CS-SS-T-mSiO2 was used as the carrier for redox and pH dual-triggered delivery of 5-fluorouracil (5-FU), an anti-cancer drug, and the results indicate that the developed CS-SS-T-mSiO2 might be a potential responsive carrier for redox and pH dual-triggered drug delivery.
Ceramics International published new progress about Amidation. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.