Oh, Sangmi; Kwon, Do Yoon; Choi, Inhee; Kim, Young Mi; Lee, Ji Young; Ryu, Jiyoung; Jeong, Hangyeol; Kim, Myung Jin; Song, Rita published an article in 2021. The article was titled 《Identification of Piperidine-3-carboxamide Derivatives Inducing Senescence-like Phenotype with Antimelanoma Activities》, and you may find the article in ACS Medicinal Chemistry Letters.COA of Formula: C5H6BNO2 The information in the text is summarized as follows:
This study evaluated the potential use of senescence-inducing small mols. in the treatment of melanoma. We screened com. available small-mol. libraries with high-throughput screening and high-content screening image-based technol. Our findings showed an initial hit with the embedded N-arylpiperidine-3-carboxamide scaffold induced senescence-like phenotypic changes in human melanoma A375 cells without serious cytotoxicity against normal cells. A focused library containing diversely modified analogs were constructed and examined to evaluate the structure-activity relationship of N-arylpiperidine-3-carboxamide derivatives starting from hit 1. This work identified a novel compound with remarkable antiproliferative activity in vitro and demonstrated the key structural moieties within. In the part of experimental materials, we found many familiar compounds, such as 2-Pyridinylboronic acid(cas: 197958-29-5COA of Formula: C5H6BNO2)
2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. COA of Formula: C5H6BNO2