In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 139585-70-9, name is 6-Bromonicotinonitrile, the common compound, a new synthetic route is introduced below. HPLC of Formula: C6H3BrN2
Step B6-(8-hydroxy-1 ,4-dioxaspiro[4.5]dec-8-yl)nicotinonitrile. A solution of 6- bromonicotinonitrile (2 g, 1 1 mmol) in 50 ml. of dry THF and 15 ml. of dry hexane under argon was cooled to -100 C in a liquid nitrogen-Et20 bath. n-Butyllithium (7.5 ml_, 1 1 mmol, 1.6 M solution in hexane) was added dropwise so that the internal temperature did not exceed -95 C. The orange solution was stirred for an additional 10 min at -100 C to -95 C and then treated dropwise over 10 min with a solution of 1 ,4-cyclohexanedione monoethylene ketal (1 .8 g, 1 1 mmol) in 55 ml. of dry THF, again carefully maintaining the temperature below -95 C. The reaction mixture was stirred for 10 min at -100 C to -95 C, allowed to warm to 20 C and poured into ice water (400 ml_). The organic layer was separated, and the aqueous layer was extracted twice with Et20 (200 ml_). The combined organic extracts were dried over MgS04 and evaporated to give 2.8 g of white crystalline solid. Trituration with Et20 afforded 1 .9 g (67% yield) of white crystals: MS: (M+H)+ 261 .
The synthetic route of 139585-70-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER LIMITED; BURGESS, Gary; WO2012/114223; (2012); A1;,
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