Venkateshwarlu, Rapolu; Nath Singh, Shambhu; Siddaiah, Vidavalur; Ramamohan, Hindupur; Dandela, Rambabu; Pal, Manojit published their research in Tetrahedron Letters on December 26 ,2019. The article was titled 《Ultrasound assisted one-pot synthesis of 1,2-diaryl azaindoles via Pd/C-Cu catalysis: Identification of potential cytotoxic agents》.Related Products of 39856-58-1 The article contains the following contents:
Ultrasound assisted one-pot and direct access to 1,2-diaryl substituted azaindole derivatives I [W = CH, N; X = CH, N; Y = CH, N; Z = CH, N; Ar1 = Ph, 4-ClC6H4, 4-MeC6H4; Ar2 = 4-CNC6H4, 4-MeOC6H4, 4-Me(SO2)C6H4, etc.] was achieved via the sequential N-arylation followed by coupling-cyclization under Pd/C-Cu catalysis. The methodol. involved initial C-N bond forming reaction (step 1) between an appropriate o-bromo substituted amino pyridine and iodoarene followed by C-C and C-N bond formation (step 2) between the resulting N-aryl substituted intermediate and a terminal alkyne in the same pot. A variety of azaindoles were prepared by using this method. These compounds were assessed for their cytotoxic properties against two different metastatic breast cancer cell lines e.g. MDA-MB-231 and MCF-7. Compounds I [W = Y = Z = CH, X = N, Ar1 = 4-MeC6H4, Ar2 = 4-MeOC6H4], I [W = Y = Z = CH, X = N, Ar1 = Ph, Ar2 = 4-MeOC6H4] and I [W = Y = Z = CH, X = N, Ar1 = 4-ClC6H4, Ar2 = 3,5-di-MeOC6H3] showed promising growth inhibition of these cell lines and SIRT1 inhibition in vitro. The results came from multiple reactions, including the reaction of 2-Bromopyridin-3-amine(cas: 39856-58-1Related Products of 39856-58-1)
2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Related Products of 39856-58-1