Product Details of 1122-54-9In 2021 ,《3H-Pyrazolo[4,3-f]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo》 appeared in Journal of Medicinal Chemistry. The author of the article were Dayal, Neetu; Reznickova, Eva; Hernandez, Delmis E.; Perina, Miroslav; Torregrosa-Allen, Sandra; Elzey, Bennett D.; Skerlova, Jana; Ajani, Haresh; Djukic, Stefan; Vojackova, Veronika; Lepsik, Martin; Rezacova, Pavlina; Krystof, Vladimir; Jorda, Radek; Sintim, Herman O.. The article conveys some information:
Herein, various 3H-pyrazolo[4,3-f]quinoline-containing compounds e.g., I were rapidly assembled via the Doebner-Povarov multicomponent reaction from the readily available 5-aminoindazoles, ketones and aldehydes in good yields. The most active compounds potently inhibit the recombinant FLT3 kinase and its mutant forms with nanomolar IC50 values. Docking studies with the FLT3 kinase showed a type I binding mode, where the 3H-pyrazolo group interacts with Cys694 in the hinge region. The compounds blocked the proliferation of AML cell lines harboring oncogenic FLT3-ITD mutations with remarkable IC50 values, which were comparable to the approved FLT3 inhibitor quizartinib. The compounds also inhibited the growth of leukemia in a mouse-disseminated AML model, and hence, the novel 3H-pyrazolo[4,3-f]quinoline-containing kinase inhibitors are potential lead compounds to develop into anticancer agents, especially for kinase-driven cancers. The results came from multiple reactions, including the reaction of 4-Acetylpyridine(cas: 1122-54-9Product Details of 1122-54-9)
4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Product Details of 1122-54-9