Quality Control of Picolinic acidIn 2019 ,《Detection of Purine Metabolite Uric Acid with Picolinic-Acid-Functionalized Metal-Organic Frameworks》 appeared in ACS Applied Materials & Interfaces. The author of the article were Qu, Shumei; Li, Zheng; Jia, Qiong. The article conveys some information:
Uric acid (UA) is a purine metabolite closely related to the metabolic function of human. Fluorescence anal. is a very effective method because of high selectivity and sensitivity but still remains a great challenge for direct UA detection. In this work, a fluorescent sensor based on postfunctionalized metal organic framework (UiO-PSM) was designed focusing on the direct detection of UA. UiO-PSM was synthesized from a zirconium-based MOF (UiO-66-NH2) and 2-picolinic acid (PA) through an amidation reaction. Because UA could quench the fluorescence of UiO-PSM through coordination, hydrogen bonding, and π-π interactions, the sensor could detect UA directly. UiO-PSM exhibited the advantages of short reaction time, high selectivity, high sensitivity, and wide linear range for UA detection. This work provided a novel method for UA detection and had potential application value in clin. diagnosis. The experimental part of the paper was very detailed, including the reaction process of Picolinic acid(cas: 98-98-6Quality Control of Picolinic acid)
Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Quality Control of Picolinic acid