Ahmad, Gulraiz; Rasool, Nasir; Qamar, Muhammad Usman; Alam, Mohammed Mujahid; Kosar, Naveen; Mahmood, Tariq; Imran, Muhammad published their research in Arabian Journal of Chemistry in 2021. The article was titled 《Facile synthesis of 4-aryl-N-(5-methyl-1H-pyrazol-3-yl)benzamides via Suzuki Miyaura reaction: Antibacterial activity against clinically isolated NDM-1-positive bacteria and their Docking Studies》.Synthetic Route of C5H6BNO2 The article contains the following contents:
The production of new pyrazole amide derivatives I (Ar = 4-AcC6H4, 4-ClC6H4, 4-MeOC6H4, etc.) and their potential against New Delhi metallo-β-lactamase-1 (NDM-1) producing bacteria was described in the present manuscript. The 4-bromo-N-(5-methyl-1H-pyrazol-3-yl)benzamide was synthesized via direct amidation of protected 5-methyl-1H-pyrazol-3-amine. The target pyrazole amide derivatives I were synthesized in moderate to excellent yield via Palladium catalyzed Suzuki cross-coupling of intermediate mol. with different aryl and heteroaryl boronic acids. The in vitro antibacterial effect against NDM-1-pos. Acinetobacter baumannii and Klebsiella pneumoniae of newly synthesized analogs I were determined by Agar well diffusion method. Moreover, MIC and MBC values were also evaluated against the tested bacteria. In addition, the Mol. Docking study of pyrazole amide derivatives I against the NDM producing A. baumannii was performed to investigate the intermol. interaction. The binding affinity and their values were compared with L-captopril. The I (Ar = 3-ClC6H4) had greatest potential value and was appeared as a promising antibacterial agent.Pyridin-3-ylboronic acid(cas: 1692-25-7Synthetic Route of C5H6BNO2) was used in this study.
Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Synthetic Route of C5H6BNO2