Application of 884494-49-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 884494-49-9, name is 2-Chloro-5-fluoro-4-iodopyridine. A new synthetic method of this compound is introduced below.
To a suspension of 2-chloro-5-fluoro-4-iodopyridine (3.18 g), 2-(4-fluoro-3-nitrophenyl)-4,4,5,5- tetramethyl-l,3,2-dioxaborolane (3.00 g) and [l, -bis(diphenylphosphino)ferrocene]dichlorpalladium(II) (complex with dichloromethane, 917 mg) in 1 ,2-dimethoxyethane (29 mL) at room temperature was added aqueous potassium carbonate solution (2M, 17 mL) and the mixture was stirred at 90 C for 3 h. The mixture was allowed to cool to room temperature, diluted with water and subsequently extracted with ethyl acetate. The combined organic layers were washed with saturated aqueous sodium chloride solution, dried and concentrated. The crude product was purified by flash column chromatography (silica gel, hexanes/ethyl acetate) to yield the title compound (2.70 g). LC-MS (method a): Rt = 1.21 min; MS (ESIpos): m/z = 271 [M+H]+ NMR (400 MHz, DMSO-i/6, 295 K) delta/ppm = 7.76 – 7.84 (m, 1H), 7.92 – 7.97 (m, 1H), 8.12 – 8.20 (m, 1H), 8.47 – 8.54 (m, 1H), 8.59 – 8.64 (m, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,884494-49-9, its application will become more common.
Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; LUeCKING, Ulrich; HOG, Daniel; CHRIST, Clara; SACK, Ulrike; SIEGEL, Franziska; LIENAU, Philip; WERBECK, Nicolas; (170 pag.)WO2018/177889; (2018); A1;,
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