In 2017,Ma, Xiantao; Yu, Lei; Su, Chenliang; Yang, Yaqi; Li, Huan; Xu, Qing published 《Efficient Generation of C-S Bonds via a By-Product-Promoted Selective Coupling of Alcohols, Organic Halides, and Thiourea》.Advanced Synthesis & Catalysis published the findings.Recommanded Product: 53939-30-3 The information in the text is summarized as follows:
A metal- and base-free three-component coupling of alcs., heteroaryl halides, and thiourea has been developed for direct and selective synthesis of heteroaryl thioethers. This method can be easily scaled up to the gram scale and extended to dialkyl thioethers, heteroaryl selenides, benzothiazoles, and some antimycobacterially-active thioethers. Mechanistic studies revealed that a byproduct-promoted in situ C-O activation of alcs. to more reactive alkyl halides and slow release of the thiol and alkyl halide intermediates are the key to the high selectivity and success of the reaction. The results came from multiple reactions, including the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Recommanded Product: 53939-30-3)
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 53939-30-3