《Photoredox Catalytic Trifluoromethylation and Perfluoroalkylation of Arenes Using Trifluoroacetic and Related Carboxylic Acids》 was written by Yin, Dehang; Su, Dengquan; Jin, Jian. Safety of Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate And the article was included in Cell Reports Physical Science on August 26 ,2020. The article conveys some information:
Here, a mild and practical method that allows for the direct C-H trifluoromethylation, perfluoroalkylation, and chlorodifluoromethylation of (hetero)arenes such as mesitylene, 1-tosyl-1H-pyrrole, N-(thiophen-3-yl)acetamide, etc. using TFA and the related carboxylic acids RC(O)OH (R = CF3, C5F11, CF2Cl, etc.) was reported. A diverse array of arenes and heteroarenes was successfully transformed into valued fluoroalkylated compounds e.g., I. The combination of photoredox catalysis and a bis(4-chlorophenyl) sulfoxide provides a platform for the facile generation of fluoroalkyl radicals from the corresponding fluoroalkyl carboxylic acids under mild conditions. After reading the article, we found that the author used Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate(cas: 77837-09-3Safety of Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate)
Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate(cas: 77837-09-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Safety of Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate Pyridine has a conjugated system of six π electrons that are delocalized over the ring.