《Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification》 was published in Nucleic Acids Research in 2020. These research results belong to Thomas, Sherine E.; Whitehouse, Andrew J.; Brown, Karen; Burbaud, Sophie; Belardinelli, Juan M.; Sangen, Jasper; Lahiri, Ramanuj; Libardo, Mark Daben J.; Gupta, Pooja; Malhotra, Sony; Boshoff, Helena I. M.; Jackson, Mary; Abell, Chris; Coyne, Anthony G.; Blundell, Tom L.; Floto, Rodrigo Andres; Mendes, Vitor. Formula: C6H7Br2N The article mentions the following:
Translational frameshift errors are often deleterious to the synthesis of functional proteins and could therefore be promoted therapeutically to kill bacteria. TrmD (tRNA-(N(1)G37) methyltransferase) is an essential tRNA modification enzyme in bacteria that prevents +1 errors in the reading frame during protein translation and represents an attractive potential target for the development of new antibiotics. Here, we describe the application of a structure-guided fragment-based drug discovery approach to the design of a new class of inhibitors against TrmD in Mycobacterium abscessus. Fragment library screening, followed by structure-guided chem. elaboration of hits, led to the rapid development of drug-like mols. with potent in vitro TrmD inhibitory activity. Several of these compounds exhibit activity against planktonic M. abscessus and M. tuberculosis as well as against intracellular M. abscessus and M. leprae, indicating their potential as the basis for a novel class of broad-spectrum mycobacterial drugs. In addition to this study using 2-(Bromomethyl)pyridine hydrobromide, there are many other studies that have used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Formula: C6H7Br2N) was used in this study.
2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Formula: C6H7Br2N