In 2018,Chen, Long; Zhu, Yueyue; Chen, Tieqiao; Liu, Long; Zhang, Ji-Shu; Han, Li-Biao published 《Direct C-OH/P(O)-H dehydration coupling forming phosphine oxides》.Organic & Biomolecular Chemistry published the findings.Reference of 2-(2-Hydroxyethyl)pyridine The information in the text is summarized as follows:
A t-BuONa-mediated C-OH/P(O)-H cross dehydration coupling to produce alkylphosphine oxides is developed. This reaction employed readily available alcs. and P(O)-H compounds as the starting materials, providing an efficient alternative method for constructing sp3 C-P bonds. A reasonable reaction path involving dehydration and subsequent regio-selective hydrophosphorylation of the resulting alkenes was proposed. In the experimental materials used by the author, we found 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Reference of 2-(2-Hydroxyethyl)pyridine)
2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Reference of 2-(2-Hydroxyethyl)pyridine