Wang, Kai; Zhou, Zhiming; Song, Jinhong; Bi, Lixue; Shen, Ning; Wu, Yukai; Chen, Fuxue; Wen, Hongliang published their research in Journal of Hazardous Materials on December 15 ,2010. The article was titled 《A metal-free aerobic oxidation of nitrotoluenes catalyzed by N,N’,N”-trihydroxyisocyanuric acid (THICA) and a novel approach to the catalyst》.Safety of 3-Nitroisonicotinic acid The article contains the following contents:
A metal-free catalytic system with N,N’,N”-trihydroxyisocyanuric acid (THICA) as the catalyst for the oxidation of nitrotoluenes is introduced, and a novel Pd-free approach for the synthesis of THICA was developed. In a solution of acetic acid, THICA and concentrated nitric acid, nitrotoluenes especially polynitrotoluenes such as 2,4,6-trinitrotoluene (TNT), were converted into the desired carboxylic acids under 0.2 MPa of O2 at 100 °C with yields up to 99%. THICA was synthesized from N-hydroxyphtalimide through a four-step synthesis in a total yield of 46%. A possible mechanism of this catalytic process was proposed where NO2 and nitric acid first induced a radical of THICA, which then abstracts a hydrogen atom from the Me on the aromatic ring to form a benzyl radical. This radical then initiates subsequent reactions. The production of the benzyl radical was supported by ESR measurements. In the experimental materials used by the author, we found 3-Nitroisonicotinic acid(cas: 59290-82-3Safety of 3-Nitroisonicotinic acid)
3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Safety of 3-Nitroisonicotinic acid