Safety of 4-CyanopyridineIn 2021 ,《Nickelocene as an Air- and Moisture-Tolerant Precatalyst in the Regioselective Synthesis of Multisubstituted Pyridines》 appeared in Journal of Organic Chemistry. The author of the article were Cho, Il Young; Kim, Woo Gyum; Jeon, Ji Hwan; Lee, Jeong Woo; Seo, Jeong Kon; Seo, Jongcheol; Hong, Sung You. The article conveys some information:
Herein, operationally simple nickel(0) catalysis to access substituted pyridines I [R = Me, Ph, 2-furyl, etc.; R1 = Me, Ph, trimethylsilyl, etc.; R2 = H, Me, Ph, etc.; Z = CH2, O, C(CO2Et)2, N-Ts] from various nitriles and 1,6-diynes without the aid of air-free techniques was reported. The Ni-Xantphos-based catalytic manifold was tolerant to air, moisture and heat while promoting the [2 + 2 + 2] cycloaddition reactions with high reaction yields and broad substrate scope. In addition, the steric effect but also the frontier MO interactions could played a critical role in determining the regiochem. outcome of nickel-catalyzed [2 + 2 + 2] cycloaddition for the synthesis of compounds I.4-Cyanopyridine(cas: 100-48-1Safety of 4-Cyanopyridine) was used in this study.
4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Safety of 4-Cyanopyridine