Application of 6271-78-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6271-78-9, name is 6-Chloropyridine-3-carboxamide. This compound has unique chemical properties. The synthetic route is as follows.
Example 754 6-(3-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}propoxy)pyridine- 3-carboxamide. A mixture of 3-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}propan- 1 -ol (intermediate 60), 6-chloropyridine-3-carboxamide (1.1 equiv.) and Cs2C03 (2.0 equiv.) in DMSO was heated in a sealed tube at 90C for 2 h. After cooling was methanol added to the solution, followed by filtration and purification by preparative LC to furnish the title compound. LCMS [M+H]+ 413. 1 H NMR (400 MHz, METHANOL-^) delta ppm 8.67 (dd, J=2.5, 0.6 Hz, 1 H), 8.13 (dd, J=8.8, 2.5 Hz, 1 H), 7.58 – 7.63 (m, 1 H), 7.29 – 7.40 (m, 2 H), 6.86 (dd, J=8.8, 0.6 Hz, 1 H), 6.03 (s, 1 H), 4.48 (t, J=6.2 Hz, 2 H), 3.72 (t, J=6.6 Hz, 2 H), 2.37 (s, 3 H), 2.15 (quin, J=6.4 Hz, 2 H).
According to the analysis of related databases, 6271-78-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; THOMAS HELLEDAYS STIFTELSE FOeR MEDICINSK FORSKNING; SCOBIE, Martin; WALLNER, Olov; KOOLMEISTER, Tobias; VALLIN, Karl Sven Axel; HENRIKSSON, Carl Martin; HOMAN, Evert; HELLEDAY, Thomas; JACQUES, Sylvain; DESROSES, Matthieu; JACQUES-CORDONNIER, Marie-Caroline; FISKESUND, Roland Julius Yu; (359 pag.)WO2015/187089; (2015); A1;,
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