Application In Synthesis of 5-Bromo-2-chloropyridineIn 2021 ,《Directing Group Enables Electrochemical Selectively Meta-Bromination of Pyridines under Mild Conditions》 appeared in Journal of Organic Chemistry. The author of the article were Wu, Yanwei; Xu, Shanghui; Wang, Hong; Shao, Dongxu; Qi, Qiqi; Lu, Yi; Ma, Li; Zhou, Jianhua; Hu, Wei; Gao, Wei; Chen, Jianbin. The article conveys some information:
Without the use of catalysts and oxidants, a facile and sustainable electrochem. bromination protocol was developed. By introducing the directing groups, the regioselectivity of pyridine derivatives could be controlled at the meta-position utilizing the inexpensive and safe bromine salts at room temperature A variety of brominated pyridine derivatives were obtained in 28-95% yields, and the reaction could be readily performed at a gram scale. By combining the installation and removing the directing group, the concept of meta-bromination of pyridines could be verified. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3Application In Synthesis of 5-Bromo-2-chloropyridine)
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application In Synthesis of 5-Bromo-2-chloropyridine