Appa, Rama Moorthy; Lakshmidevi, Jangam; Naidu, Bandameeda Ramesh; Venkateswarlu, Katta published their research in Molecular Catalysis in 2021. The article was titled 《Pd-catalyzed oxidative homocoupling of arylboronic acids in WEPA: A sustainable access to symmetrical biaryls under added base and ligand-free ambient conditions》.Safety of 2-Pyridinylboronic acid The article contains the following contents:
A quick and eco-friendly protocol for the synthesis of biaryls, e.g., I by an oxidative (aerobic) homocoupling of arylboronic acids RB(OH)2 (R = C6H5, pyridin-2-yl, 2-thienyl, etc.) using Pd(OAc)2 in water extract of pomogranate ash (WEPA) as an efficient agro-waste(bio)-derived aqueous (basic) media is described. The reactions were executed at ambient aerobic conditions in the absence of external base and ligand to result sym. biaryls in excellent yields. The use of renewable media with an effective exploitation of waste, short reaction times, excellent yields of products, easy separation of the products, unnecessating the external base, oxidant, ligand or volatile organic solvents and ambient reaction conditions are the vital insights of the present protocol.2-Pyridinylboronic acid(cas: 197958-29-5Safety of 2-Pyridinylboronic acid) was used in this study.
2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Safety of 2-Pyridinylboronic acid