Computed Properties of C5H3Br2NIn 2020 ,《Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties》 appeared in Journal of Medicinal Chemistry. The author of the article were Chen, Hao; Deng, Shanshan; Wang, Yuxi; Albadari, Najah; Kumar, Gyanendra; Ma, Dejian; Li, Weimin; White, Stephen W.; Miller, Duane D.; Li, Wei. The article conveys some information:
We recently reported the crystal structure of tubulin in complex with a colchicine binding site inhibitor (CBSI), ABI-231, having 2-aryl-4-benzoyl-imidazole (ABI). Based on this and addnl. crystal structures, here we report the structure-activity relationship study of a novel series of pyridine analogs of ABI-231, with compound 4v being the most potent one (average IC50 ∼ 1.8 nM) against a panel of cancer cell lines. We determined the crystal structures of another potent CBSI ABI-274 and 4v in complex with tubulin and confirmed their direct binding at the colchicine site. 4v inhibited tubulin polymerization, strongly suppressed A375 melanoma tumor growth, induced tumor necrosis, disrupted tumor angiogenesis, and led to tumor cell apoptosis in vivo. Collectively, these studies suggest that 4v represents a promising new generation of tubulin inhibitors.2,6-Dibromopyridine(cas: 626-05-1Computed Properties of C5H3Br2N) was used in this study.
2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Computed Properties of C5H3Br2N