Yadav, Eqvinshi; Khatana, Anil Kumar; Sebastian, Sharol; Gupta, Manoj K. published their research in New Journal of Chemistry in 2021. The article was titled 《DAP derived fatty acid amide organogelators as novel carrier for drug incorporation and pH-responsive release》.Related Products of 141-86-6 The article contains the following contents:
Inflammation is associated with many different class of diseases and NSAIDs (non-steroidal anti-inflammatory drugs) are mostly preferred for long-term use. Although they are safe to use, some serious side effects are associated with these class of compounds; therefore, local drug delivery is an option to minimize the side effects. In this study, we have designed a new gel formulation for topical and transdermal applications of the NSAIDs with enhanced properties. For this purpose, low mol. mass DAP (2,6-diaminopyridine) derived fatty acid amides with varying alkyl chain lengths are synthesized. These fatty acid amides form stable self-assembled aggregates in organic solvents as well as in organic and aqueous solvent mixtures affording organogels and bigels, resp. The min. gelation concentration (MGC) of the organic gel is 0.5% w/v, which behaves as a super gelator. The various functionality present in the DAP-derived fatty acid amide gelators play an important role in the self-aggregation such as pyridine moiety stack through π-π and alkyl chain via van der Waals interactions resulting in the formation of stable organo and bigels network. The prepared organogel emulsions with these fatty acid amides are capable to encapsulate and release the drug mol. ibuprofen at room temperature without altering its structure and activity. Therefore, these analogs can be successfully utilized in pharmaceutical industries as a novel drug delivery carrier.2,6-Diaminopyridine(cas: 141-86-6Related Products of 141-86-6) was used in this study.
2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Related Products of 141-86-6