Wu, Ye-bin; Wu, You-zhi; Wu, Jian; Xu, Dan; Jiang, Hui; Chang, Wen-wu; Ma, Chang-you published their research in Journal of Organic Chemistry in 2021. The article was titled 《Copper-Catalyzed Regioselective Coupling of Tosylhydrazones and 2-Pyridones: A Strategy for the Production of N-Alkylated Compounds》.Synthetic Route of C7H7NO The article contains the following contents:
The highly regioselective N-alkylation reaction of 2-pyridones was achieved through hydrazone chem., especially for substrates with bulky secondary alkyl groups. Herein, a copper-catalyzed regioselective coupling of tosylhydrazones and 2-pyridones/isoquinolinones for the synthesis of N-alkylated compound such as N-alkylated pyridones I [R = CH(Me)(4-MeOC6H4), R1 = H, CN, C(O)OMe; R2 = H, OMe; R3 = H, F, Br] isoquinolinones II [R1 = H, Me; R2 = Ph, 3-O2NC6H4, 2-ClC6H4, etc.] was described. The experimental process involved the reaction of 4-Acetylpyridine(cas: 1122-54-9Synthetic Route of C7H7NO)
4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Synthetic Route of C7H7NO