The author of 《Role of the kynurenine pathway and the endocannabinoid system as modulators of inflammation and personality traits》 were Heilman, Patrick; Hill, Matthew N.; Coussons-Read, Mary; Brundin, Lena; Coccaro, Emil F.. And the article was published in Psychoneuroendocrinology in 2019. Quality Control of Picolinic acid The author mentioned the following in the article:
Kynurenine pathway metabolites and endocannabinoids both exert potent regulatory effects on the immune system, but the relationship between these mols. is unknown. The role of these immunobiol. mediators in emotionality and personality traits is not previously characterized. Interleukin-6 (IL-6), 2-arachidonoylglycerol (2-AG) and picolinic acid (PIC) were measured in the plasma of phys. healthy individuals who had history of mood, anxiety, and personality disorders (n = 96) or who had no history of any psychiatric disorder (n = 56) by DSM-5 Criteria. Dimensional assessments of personality were performed using the Eysenck Personality Questionnaire (EPQ) and the Tridimensional Personality Questionnaire (TPQ). Plasma IL-6 levels were significantly associated with plasma 2-AG levels and plasma PIC levels across all subjects. PIC levels were also neg. associated with 2-AG levels across all subjects, independent of IL-6 levels. In our anal. of the biol. determinants of personality factors, we identified significant associations between IL-6 and novelty seeking assessment, and between PIC and neuroticism assessment. These data provide evidence of a biol. link between metabolites of the kynurenine pathway, the endocannabinoid system and IL-6 and suggest that these factors may influence personality traits. After reading the article, we found that the author used Picolinic acid(cas: 98-98-6Quality Control of Picolinic acid)
Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Quality Control of Picolinic acid