Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19337-97-4, name is trans-3-(3-Pyridyl)acrylic acid. A new synthetic method of this compound is introduced below., SDS of cas: 19337-97-4
Compound 5-3 (2.5 g, 6 mmol) was dissolved in dichloromethane (25 ml), trifluoroacetic acid (5 ml) was added,The solvent was evaporated under reduced pressure for 2 hours to give a brown oil.The reaction mixture was dissolved in dichloromethane (40 ml), and N, N-diisopropylethylamine (2.14 ml, 12 mmol), trans-3 (3-pyridyl) allyl (893 mg, 3 mmol) (2.3 g, 12 mmol), DMAP (145 mg, 0.12 mmol), reacted at room temperature for 8 hours,Saturated ammonium chloride (50 ml) was added and extracted with dichloromethane (50 ml x 3). The combined organic layers were dried over anhydrous sodium sulfate and filtered. The solvent was evaporated under reduced pressure and subjected to column chromatography to give compound 2 ((E) -N- 5- (3- (2-amino-6- (cyclopropylamino) pyrimidin-4-yl) phenol) pentyl) -3- (pyridin-3-yl) acrylamide) (1.7 g, ).
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Reference:
Patent; Chinese Academy Of Sciences Guangzhou Bio-pharmaceutical And Health Institute; Chinese Academy Of Sciences Shanghai Organic Chemistry Institute; China Pharmaceutical University; Jiang Sheng; Tu Zhengchao; Zhu Jidong; Yao Hequan; Yao Yiwu; Tan Xiaochu; Gu Shoulai; Qiu Yatao; (30 pag.)CN106928192; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem