In 2020,Dalton Transactions included an article by Busto, Natalia; Carrion, M. Carmen; Montanaro, Sonia; Diaz de Grenu, Borja; Biver, Tarita; Jalon, Felix A.; Manzano, Blanca R.; Garcia, Begona. Category: pyridine-derivatives. The article was titled 《Targeting G-quadruplex structures with Zn(II) terpyridine derivatives: a SAR study》. The information in the text is summarized as follows:
Based on the ability of terpyridines to react with G-quadruplex DNA (G4) structures along with the interest aroused by Zn as an essential metal center in many biol. processes, the authors synthesized and characterized six Zn chloride or nitrate complexes containing terpyridine ligands with different 4′-substituents. The authors have studied their interaction with G4 and their cytotoxicity. The exptl. results revealed that the leaving group exerts a strong influence on the cytotoxicity, since the complexes bearing chloride were more cytotoxic than their nitrate analogs and an effect of the terpyridine ligand was also observed The thermal stabilization profiles showed that the greatest stabilization of hybrid G4, Tel22, was observed for the Zn complexes bearing the terpyridine ligand that contained one or two methylated 4-(imidazol-1-yl)phenyl substituents, 3Cl and 3(L)2, resp., probably due to their extra pos. charge. Stability and aquation studies for these complexes were carried out and no ligand release was detected. Complexes 3Cl and 3(L)2 were successfully internalized by SW480 cells and they seemed to be localized mainly in the nucleolus. The highest cytotoxicity, G4 selectivity and G4 affinity determined by fluorescence and ITC experiments, and subcellular localization quantified by ICP-MS measurements, rendered 3Cl a very interesting complex from a biol. standpoint. The experimental process involved the reaction of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Category: pyridine-derivatives)
4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Category: pyridine-derivativesThe lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.