Application In Synthesis of Picolinic acidIn 2020 ,《Ilex paraguariensis, white mulberry and chromium picolinate in patients with pre-diabetes》 appeared in Phytotherapy Research. The author of the article were Derosa, Giuseppe; D’Angelo, Angela; Maffioli, Pamela. The article conveys some information:
To evaluate if a nutraceutical compound containing Ilex paraguariensis, White Mulberry and Chromium Picolinate can ameliorate glycemic status in patients with pre-diabetes. We enrolled patients with IFG or IGT, not taking other hypoglycemic compounds Patients were randomized to take placebo or the nutraceutical compound for 3 mo, in a randomized, double-blind, placebo-controlled design. Both treatments were self-administered once a day, 1 tablet during the breakfast. A reduction of FPG was observed with the nutraceutical combination (-7.8%). Furthermore, there was a decrease of HOMA-IR with the nutraceutical combination (-7.9%). M value was higher (p < 0.05 vs baseline and p < 0.05 vs placebo) at the end of the treatment. We obtained a reduction of Tg with the nutraceutical combination (-8.3%). About 16.6% of patients treated with nutraceutical returned to have a normal glycemia (< 100 mg/dL), and all patients had an improvement of insulin-resistance, in particular 67% of patients returned to have a M value inside range of normal insulin sensitivity. A nutraceutical containing Ilex paraguariensis, White Mulberry and Chromium Picolinate at 500 mg can be helpful in improving glycemia and Tg value, in patients with pre-diabetes. The experimental part of the paper was very detailed, including the reaction process of Picolinic acid(cas: 98-98-6Application In Synthesis of Picolinic acid)
Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Application In Synthesis of Picolinic acid