In 2019,Biosensors & Bioelectronics included an article by Song, Juan; Ni, Jiancong; Wang, Qinghua; Chen, Huangcan; Gao, Feng; Lin, Zhenyu; Wang, Qingxiang. Reference of Picolinic acid. The article was titled 《A planar and uncharged copper(II)-picolinic acid chelate: Its intercalation to duplex DNA by experimental and theoretical studies and electrochemical sensing application》. The information in the text is summarized as follows:
Using an external redox-active mol. as a DNA hybridization indicator is still a popular strategy in electrochem. DNA biosensors because it is label-free and the multi-site binding can enhance the response signal. A planar and uncharged transition metal complex, Cu(PA)2 (PA = picolinic acid) with excellent electrochem. activity has been synthesized and its interaction with double-stranded DNA (dsDNA) is studied by exptl. electrochem. methods and theor. mol. docking technol. The exptl. results reveal that the copper complex interacts with dsDNA via specific intercalation, which is verified by the mol. docking result. The surface-based voltammetric anal. demonstrates that the planar Cu(PA)2 can effectively accumulate within the electrode-confined hybridized duplex DNA rather than the single-stranded probe DNA. Based on this phenomenon, the Cu(PA)2 is utilized as an electrochem. hybridization indicator for the detection of oligonucleotides. The sensing assays show that upon incubation in Cu(PA)2 solution, the probe electrode does not display any Faraday signal, but the hybridized one has a pair of strong redox peaks corresponding to the electrochem. of Cu(PA)2, showing excellent hybridization indicating function of Cu(PA)2 without background interference. The signal intensity of Cu(PA)2 is dependent on the concentrations of the target oligonucleotide ranging from 1 fM to 100 nM with an exptl. detection limit of 1.0 fM. Due to the specific intercalation of Cu(PA)2 with dsDNA, the biosensor also exhibits good ability to recognize oligonucleotide with different base mismatching degree. After reading the article, we found that the author used Picolinic acid(cas: 98-98-6Reference of Picolinic acid)
Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Reference of Picolinic acid