In 2017,Bhatt, V. P.; Samant, S. D.; Pednekar, Suhas published 《Nucleophilic addition of arylmethylzinc reagents (ArCH2ZnCl) to formaldehyde: An easy access to 2-(hetero)arylethyl alcohols》.Synthetic Communications published the findings.Category: pyridine-derivatives The information in the text is summarized as follows:
The nucleophilic addition of benzyl zinc reagents derived from inexpensive and abundant benzyl chlorides to paraformaldehyde was reported. The reaction investigated herein is hitherto unknown and was found to be selective, operationally simple, atom- and step-economical and high yielding to deliver phenethyl alcs. utilized as key perfumery ingredients in 60-83% yields. After successful establishment of the reaction condition, the reaction was also scaled up successfully to deliver a large-scale preparation of the phenethyl alc.2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Category: pyridine-derivatives) was used in this study.
2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Category: pyridine-derivatives