In 2013,Sharma, Sushila; Kumar, Manoranjan; Kumar, Vishal; Kumar, Neeraj published 《Vasicine catalyzed direct C-H arylation of unactivated arenes: organocatalytic application of an abundant alkaloid》.Tetrahedron Letters published the findings.Application of 13534-97-9 The information in the text is summarized as follows:
Vasicine, a quinazoline alkaloid isolated from Adhatoda vasica, has been employed as an organocatalyst for direct C-H arylation of unactivated arenes with aryl iodides/bromides without the assistance of any transition metal catalyst. A number of sensitive functional groups such as Me, methoxy, O-benzyl, acetyl, and amino were well tolerated under present reaction conditions. Mechanistic investigation supported the involvement of radical intermediates.6-Bromopyridin-3-amine(cas: 13534-97-9Application of 13534-97-9) was used in this study.
6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Application of 13534-97-9