Related Products of 55758-32-2, Adding some certain compound to certain chemical reactions, such as: 55758-32-2, name is 6-Fluoropyridin-3-ol,molecular formula is C5H4FNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55758-32-2.
Step 2: To a solution of 6-fluoropyridin-3-ol (75 g, 663 mmol) in DMF (265 mL, 663 mmol) were added potassium carbonate (59.7 g, 995 mmol) and iodomethane (108 g, 763 mmol). The resulting slurry was heated at 100 C for 3 hours. The reaction was diluted with water (1000 mL) and poured into a separatory funnel containing diethyl ether (1000 mL). The layers were separated and the aqueous layer was extracted with diethyl ether (4 x 500 mL). The combined organic layers were washed with water and then brine, dried over sodium sulfate, filtered and concentrated in vacuo to provide a yellow oil. This oil was diluted with 500 mL of DCM and concentrated to provide a yellow oil with a large amount of an off white precipitate. The mixture was filtered and the derived solid was washed well with DCM. The filtrate was concentrate to provide a mixture consisting of a yellow oil and an off white solid. The solid was filtered, washing with DCM. Repeat this procedure again and then concentrated the filtrate to provide a yellow oil. The oil was taken up in 100 mL of ether and flashed through a plug of silica gel with 10:1 hexanes:ether to provide 2-fluoro-5-methoxypyridine as a yellow oil.
According to the analysis of related databases, 55758-32-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AMGEN INC.; MINATTI, Ana Elena; EPSTEIN, Oleg; WHITE, Ryan; WEISS, Matthew; ZHONG, Wenge; LOW, Jonathan; WO2012/71279; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem