In 2018,Green Chemistry included an article by Chakrabarti, Kaushik; Mishra, Anju; Panja, Dibyajyoti; Paul, Bhaskar; Kundu, Sabuj. Reference of 2-(2-Hydroxyethyl)pyridine. The article was titled 《Selective synthesis of mono- and di-methylated amines using methanol and sodium azide as C1 and N1 sources》. The information in the text is summarized as follows:
A Ru(II) complex mediated synthesis of various N,N-di-Me and N-monomethyl amines from organic azides using methanol as a methylating agent was reported. This methodol. was successfully applied for a one-pot reaction of bromide derivatives and sodium azide in methanol. Notably, by controlling the reaction time several N-monomethylated and N,N-dimethylated amines were synthesized selectively. The practical applicability of this tandem process was revealed by preparative scale reactions with different organic azides and synthesis of an anti-vertigo drug betahistine. Several kinetic experiments and DFT studies were carried out to understand the mechanism of this transformation. In the experiment, the researchers used many compounds, for example, 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Reference of 2-(2-Hydroxyethyl)pyridine)
2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Reference of 2-(2-Hydroxyethyl)pyridine