《Design, synthesis, characterization of peripherally tetra-pyridine-triazole-substituted phthalocyanines and their inhibitory effects on cholinesterases (AChE/BChE) and carbonic anhydrases (hCA I, II and IX)》 was published in Dalton Transactions in 2020. These research results belong to Arslan, Tayfun; Bugrahan Ceylan, M.; Bas, Huseyin; Biyiklioglu, Zekeriya; Senturk, Murat. Quality Control of 4-Ethynylpyridine The article mentions the following:
In this study, phthalocyanine precursors (5 and 9) and 1,2,3-triazole-substituted metal-free and metallo phthalocyanines (9a-c) were designed and synthesized for the first time and evaluated in vitro for key mol. targets. The structures of the novel compounds were characterized via FT-IR, 1H/13C NMR, UV-Vis, and mass spectroscopy. The inhibitory activities of the compounds were tested against human carbonic anhydrase isoforms hCA I, II (cytosolic, ubiquitous isoenzymes), and IX (transmembrane, cancer-associated isoenzyme) and cholinesterases (AChE and BChE, which are associated with Alzheimer’s disease). Among the three phthalocyanines and starting compounds, 9b showed the most interesting profile as a nanomolar selective inhibitor of hCA I (Ki = 37.2 nM) and 9c showed the most effective inhibitory effect on hCA II, IX, AChE and BChE (Ki = 41.9, 27.4, 5.8 and 45.8 nM, resp.). This study is also the first example of cancer-associated isoenzyme hCA IX inhibition by phthalocyanines. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7Quality Control of 4-Ethynylpyridine)
4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Quality Control of 4-Ethynylpyridine