Safety of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acidOn March 31, 1995, Monge, A.; Martinez-Merino, V.; Simon, M. A.; Sanmartin, C. published an article in Arzneimittel-Forschung. The article was 《New 5H-[1,3]thiazolo[3,2-a]pyrido[3,2-e]pyrimidin-5-one derivatives as diuretics》. The article mentions the following:
A series of new 5H-[1,3]thiazolo[3,2-a]pyrido[3.2-3]pyrimidin-5-ones 3-substituted and/or 8,9-hydrogenated was prepared and tested for their diuretic, natriuretic and kaliuretic activities on male Wistar rats at a dosage of 25 mg/kg or less. Diuretic and saliuretic activities were strongly influenced by substituents in 3-position. Quant. structure-activity relationships show that electron withdrawn substituents in 3-position enhance both diuretic and saliuretic activities at 25 mg/kg. Global anal. of the variations introduced on pyridine, pyrimidine and thiazole rings of this tricyclic system showed an increases of diuretic and natriuretic activities when the formal charge on N9a and C9b increases. Potassium ion excretion also increases, although not as drastically a in the earlier cases. Regression equations were calculated by partial least squares method (PLS) and validated by the cross-validation (leave-one-out) technique. The results came from multiple reactions, including the reaction of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9Safety of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid)
2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Safety of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acidThe lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.