Pei, Di; Liu, Bo; Zhao, Shuai; Shu, Xin; Nie, Jun; Chang, Yincheng published their research in ACS Applied Bio Materials in 2021. The article was titled 《Controllable Release Mode Based on ATP Hydrolysis-Fueled Supra-Amphiphile Assembly》.Formula: C12H13N3 The article contains the following contents:
The controllable intermittent and stepwise release modes were achieved in a dissipative system of supra-amphiphile. The supra-amphiphile was constructed based on complexation of cationic amphiphile (Zn@DPA-14) and biol. energy currency, ATP. The formation of supra-amphiphile and the competing hydrolysis of ATP by enzyme drove the micelles assembled by Zn@DPA-14 away from the thermodn. equilibrium state, leading to the cargo release from micelles during the process of micelles transformed to vesicles. Following the time-dependent evolution, the intermittent release or stepwise release modes of the loaded cargo realized through adjusting the polarity of the cargo mols. The strategy advancing from “”traditional”” release modes under thermodn. control toward the life-like controllable modes in the far-from-equilibrium state shows unique potential applications on transport vehicles and biomedical field. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Formula: C12H13N3) was used in this study.
Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Formula: C12H13N3