Safety of 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridineOn October 11, 2007 ,《Dipole-LUMO/Dipolarophile-HOMO Controlled Asymmetric Cycloadditions of Carbonyl Ylides Catalyzed by Chiral Lewis Acids》 was published in Organic Letters. The article was written by Suga, Hiroyuki; Ishimoto, Daisuke; Higuchi, Satoshi; Ohtsuka, Motoo; Arikawa, Tadashi; Tsuchida, Teruko; Kakehi, Akikazu; Baba, Toshihide. The article contains the following contents:
We have found the first successful example of reverse-electron-demand dipole-LUMO/dipolarophile-HOMO controlled cycloaddition reactions between carbonyl ylides, which were generated from o-methoxycarbonyl-α-diazoacetophenone and their acyl derivatives as precursors, and vinyl ether derivatives with high levels of asym. induction (97-77% ee) using chiral 2,6-(oxazolinyl)pyridine-Eu(III) or binaphthyldiimine-Ni(II) complexes as chiral Lewis acid catalysts. In addition to this study using 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine, there are many other studies that have used 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7Safety of 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine) was used in this study.
2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Safety of 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine Pyridine has a conjugated system of six π electrons that are delocalized over the ring.