Reference of 2-(Bromomethyl)pyridine hydrobromideIn 2016 ,《Synthesis and structural analyses of phenylethynyl-substituted tris(2-pyridylmethyl)amines and their copper(II) complexes》 appeared in Dalton Transactions. The author of the article were Lim, Jaebum; Lynch, Vincent M.; Edupuganti, Ramakrishna; Ellington, Andrew; Anslyn, Eric V.. The article conveys some information:
Three new tris(2-pyridylmethyl)amine-based ligands possessing phenylethynyl units were prepared using Sonogashira couplings and substitution reactions. Copper(II) complexes (I) of those tetradentate ligands also were synthesized. Solid-state structures of the six new compounds were determined by single-crystal x-ray diffraction analyses. Examination of the mol. structures of the ligands revealed the expected triangular geometries with virtually undeformed carbon-carbon triple bonds. While the tertiary nitrogen of the free ligands seem to be prevented from participation in supramol. noncovalent interactions by the pyridyl hydrogen at the 3-position, the pyridyl nitrogens play a crucial role in the packing mode of the crystal structure. The nitrogens form weak hydrogen bonds, varied at 2.32-2.66 Å, with the pyridyl hydrogen of its neighboring mol. The [N···H-C] contacts enforce one-dimensional columnar assemblies on ligands that organize into wall-like structures, which in turn assemble into three-dimensional structures through CH-π interactions. Structural analyses of Cu(II) complexes of the ligands revealed propeller-like structures caused by steric crowding of three pyridine ligands. The copper complexes of the ligands having three phenylethynyl substituents showed a remarkably deformed carbon-carbon triple bond enforced by a steric effect of the three Ph groups. Most significantly, a total of seventy noncovalent interactions, classified into twelve types of hydrogen-involving short contacts, were identified. The phenylethynyl substituent participated in forty-two interactions as a hydrogen bond acceptor, and its role was more distinctive in the crystal structures of the Cu(II) complexes. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Reference of 2-(Bromomethyl)pyridine hydrobromide)
2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Reference of 2-(Bromomethyl)pyridine hydrobromide