On October 5, 2018, Park, Hojoon; Chekshin, Nikita; Shen, Peng-Xiang; Yu, Jin-Quan published an article.Safety of Pyridine-3-sulfonic acid The title of the article was Ligand-Enabled, Palladium-Catalyzed β-C(sp3)-H Arylation of Weinreb Amides. And the article contained the following:
Authors report the development of Pd(II)-catalyzed C(sp3)-H arylation of Weinreb amides. Both the inductive effect and the potential bidentate coordination mode of the Weinreb amides pose a unique challenge for this reaction development. A pyridinesulfonic acid ligand is designed to accommodate the weak, neutral-coordinating property of Weinreb amides by preserving the cationic character of Pd center through zwitterionic assembly of Pd/ligand complexes. D. functional theory (DFT) studies of the C-H cleavage step indicate that the superior reactivity of 3-pyridinesulfonic acid ligand, compared to Ac-Gly-OH and ligandless conditions, originates from the stabilization of overall substrate-bound Pd species. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Safety of Pyridine-3-sulfonic acid
The Article related to ligand palladium catalyzed beta carbon hydrogen arylation weinreb amide, crystal mol structure methyl fluorobenzyl methoxymethylcarbamoylcyclopropyl benzoate, mol structure calculation palladium weinreb amide complex intermediate, c(sp3)–h activation, ligand design, palladium, pyridinesulfonic acid, weinreb amide and other aspects.Safety of Pyridine-3-sulfonic acid