Rieder, Samuel; Melendez, Camilo; Denes, Fabrice; Jangra, Harish; Mulliri, Kleni; Zipse, Hendrik; Renaud, Philippe published an article in 2021, the title of the article was Radical chain monoalkylation of pyridines.SDS of cas: 908267-63-0 And the article contains the following content:
The monoalkylation of N-methoxypyridinium salts with alkyl radicals generated from alkenes (via hydroboration with catecholborane), alkyl iodides (via iodine atom transfer) and xanthates to afford alkylated quinoline derivatives R-R1 [R = 4-methylquinolinyl, 4-Cl-quinolinyl, 3-Br-quinolinyl, etc.; R1 = Et, iPr, cyclohexyl, etc.] and pyridine derivatives R2-R3 [R2 = 4-phenylpyridinyl, 4-tBu-pyridinyl, 4-Br-pyridinyl, etc.; R3 = iPr, 1-adamantyl, cyclohexyl, etc.] was reported. The reaction proceeded under neutral conditions since no acid was needed to activate the heterocycle and no external oxidant was required. A rate constant for the addition of a primary radical to N-methoxylepidinium >107 M-1 s-1 was exptl. determined This rate constant was more than one order of magnitude larger than the one measured for the addition of primary alkyl radicals to protonated lepidine demonstrating the remarkable reactivity of methoxypyridinium salts toward radicals. The reaction was used for the preparation of unique pyridinylated terpenoids and was extended to a three-component carbopyridinylation of electron-rich alkenes including enol esters, enol ethers and enamides. The experimental process involved the reaction of 4-Bromo-2-isopropylpyridine(cas: 908267-63-0).SDS of cas: 908267-63-0
The Article related to alkylated pyridine derivative preparation, pyridine derivative alkene monoalkylation, alkyl iodide pyridine derivative monoalkylation, xanthate pyridine derivative monoalkylation, derivative pyridine alkylated preparation, ester alkene pyridine derivative three component carbopyridinylation and other aspects.SDS of cas: 908267-63-0