According to the analysis of related databases, 20173-24-4, the application of this compound in the production field has become more and more popular.
Related Products of 20173-24-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 20173-24-4, name is 2-(Pyridin-3-yl)ethanamine, molecular formula is C7H10N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 157: 3-Fluoro-8-isopropyl-11 -oxo-/V-(2-pyridin-3-ylethyl)-10,11 – dihydrodibenzo[6,/][1 ,4]thiazepine-7-sulfonamide 5,5-dioxide [0487] Triethylamine (0.173 g, 1.71 mmol) and 3-(2-aminoethyl)pyridine (0.114 g, 0.930 mmol) were dissolved in dichloromethane (5 ml_), and 3-fluoro-8-isopropyl-5,5- dioxido-11-oxo-10,11-dihydrodibenzo[6,r][1 ,4]thiazepine-7-sulfonyl chloride (6.25 ml_ of 0.124 M solution, 0.775 mmol) was added as a solution in dichloromethane. The mixture was stirred 16 hours at room temperature, then poured into dilute hydrochloric acid. The aqueous layer was extracted twice with dichloromethane, and the combined organic layers were dried over magnesium sulfate and concentrated to afford a brown oil, which was purified by silica gel column chromatography (hexane/ethyl acetate/methanol, 90/9/1 to 0/90/10) to afford 3-fluoro-8-isopropyl-11- oxo-/V-(2-pyridin-3-ylethyl)-10, 11 -dihydrodibenzo[6, /][1 ,4]thiazepine-7-sulfonamide 5,5-dioxide (0.050 g) as a white solid.MS (ES) m/z 503.8;HPLC purity 95.5% at 210-370 nm, 8.5 minutes.; Xterra RP 18, 3.5u, 150 x 4.6 mm column, 1.2 mL/min, 85/15-5/95 (Ammon. Form. Buff. Ph=3.5/ACN+MeOH) for 10 minutes, hold 4 minutes.HRMS: calculated for C23H22FN3O5S2 + H+, 504.10577; found (ESI1 [M+H]+), 504.1046;
According to the analysis of related databases, 20173-24-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; WYETH; WO2008/61029; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem