Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Formula: C5H3BrFN.
Ma, Bei-Bei;Lan, Xiao-Bing;Shen, Dong-Sheng;Liu, Feng-Shou;Xu, Chang research published 《 Direct C-H bond (Hetero)arylation of thiazole derivatives at 5-position catalyzed by N-heterocyclic carbene palladium complexes at low catalyst loadings under aerobic conditions》, the research content is summarized as follows. A highly efficient and practical protocol has been developed for the synthesis of 5-(hetero)arylated thiazole derivatives I [R = pyridin-3-yl, pyrimidin-5-yl, 4-(trifluoromethyl)phenyl, etc.; R1 = H, Me; R2 = H, Me] via an N-heterocyclic carbene palladium (Pd-NHC) complex catalyzed direct C-H arylation reaction. Utilization of this methodol., the arylation of substituted thiazoles I (R = H) with (hetero)aryl bromides RBr efficiently proceeded at low catalyst loading (0.1-0.05 mol%) and under aerobic conditions. A variety of (hetero)aryl bromides, even some strongly deactivated or highly congested (hetero)aryl bromides, with a broad range of functional groups was compatible under the optimal reaction conditions. In all cases, the target products were produced in moderate to quant. yields.
Formula: C5H3BrFN, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , 766-11-0.